The Houston Texans hold the edge in AFC South title odds thanks to their elite defensive unit, which ranked first in total defense in 2025 and returns nearly every key starter, including edge rushers and coverage playmakers. This allows quarterback C.J. Stroud more margin for error while an upgraded offensive line and added running back depth ease pressure on the offense. The Jacksonville Jaguars remain close behind as defending division champions with a potent passing attack led by Trevor Lawrence and continuity under their coaching staff, though roster turnover at skill positions and a tougher schedule introduce uncertainty. Indianapolis projects as a distant third with Daniel Jones returning from injury but lingering questions around defensive front production, while the Titans sit last amid ongoing rebuilding and limited win expectations for Cam Ward. Preseason roster moves and camp reports have reinforced these relative strengths without major shifts.